Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: Impact of tyrosine kinase inhibitor and minimal residual disease
Identifieur interne : 004558 ( Main/Exploration ); précédent : 004557; suivant : 004559Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: Impact of tyrosine kinase inhibitor and minimal residual disease
Auteurs : Veronika Bachanova [États-Unis] ; David I. Marks [Royaume-Uni] ; Mei-Jie Zhang [États-Unis] ; Hailin Wang [États-Unis] ; Marcos De Lima [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Martha Arellano [États-Unis] ; Andrew S. Artz [États-Unis] ; Ulrike Bacher [Allemagne] ; Jean-Yves Cahn [France] ; Yi-Bin Chen [États-Unis] ; Edward A. Copelan [États-Unis] ; William R. Drobyski [États-Unis] ; Robert Peter Gale [Royaume-Uni] ; John P. Greer [États-Unis] ; Vikas Gupta [Canada] ; Gregory A. Hale [États-Unis] ; Partow Kebriaei [États-Unis] ; Hillard M. Lazarus [États-Unis] ; Ian D. Lewis [Australie] ; Victor A. Lewis [Canada] ; Jane L. Liesveld [États-Unis] ; Mark R. Litzow [États-Unis] ; Alison W. Loren [États-Unis] ; Alan M. Miller [États-Unis] ; Maxim Norkin [États-Unis] ; Betul Oran [États-Unis] ; Joseph Pidala [États-Unis] ; Jacob M. Rowe [Israël] ; Bipin N. Savani [États-Unis] ; Wael Saber [États-Unis] ; Ravi Vij [États-Unis] ; Edmund K. Waller [États-Unis] ; Peter H. Wiernik [États-Unis] ; Daniel J. Weisdorf [États-Unis]Source :
- Leukemia [ 0887-6924 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Chromosome Philadelphie, Cochons d'Inde, Conditionnement pour greffe, Femelle, Humains, Induction de rémission, Jeune adulte, Leucémie-lymphome lymphoblastique à précurseurs B et T (), Leucémie-lymphome lymphoblastique à précurseurs B et T (anatomopathologie), Maladie résiduelle, Mâle, Protein-tyrosine kinases (antagonistes et inhibiteurs), Taux de survie, Transplantation de moelle osseuse, Transplantation homologue.
- MESH :
- anatomopathologie : Leucémie-lymphome lymphoblastique à précurseurs B et T.
- antagonistes et inhibiteurs : Protein-tyrosine kinases.
- Adulte, Adulte d'âge moyen, Animaux, Chromosome Philadelphie, Cochons d'Inde, Conditionnement pour greffe, Femelle, Humains, Induction de rémission, Jeune adulte, Leucémie-lymphome lymphoblastique à précurseurs B et T, Maladie résiduelle, Mâle, Taux de survie, Transplantation de moelle osseuse, Transplantation homologue.
English descriptors
- KwdEn :
- Adult, Animals, Bone Marrow Transplantation, Female, Guinea Pigs, Humans, Male, Middle Aged, Neoplasm, Residual, Philadelphia Chromosome, Precursor Cell Lymphoblastic Leukemia-Lymphoma (pathology), Precursor Cell Lymphoblastic Leukemia-Lymphoma (surgery), Protein-Tyrosine Kinases (antagonists & inhibitors), Remission Induction, Survival Rate, Transplantation Conditioning, Transplantation, Homologous, Young Adult.
- MESH :
- chemical , antagonists & inhibitors : Protein-Tyrosine Kinases.
- pathology : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- surgery : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- Adult, Animals, Bone Marrow Transplantation, Female, Guinea Pigs, Humans, Male, Middle Aged, Neoplasm, Residual, Philadelphia Chromosome, Remission Induction, Survival Rate, Transplantation Conditioning, Transplantation, Homologous, Young Adult.
Abstract
The efficacy of reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) for Ph+ acute lymphoblastic leukemia (ALL) is uncertain. We analyzed 197 adults with Ph+ ALL in first complete remission; 67 patients receiving RIC were matched with 130 receiving myeloablative conditioning (MAC) for age, donor type, and HCT year. Over 75% received pre-HCT tyrosine kinase inhibitors (TKI), mostly imatinib; 39% (RIC) and 49% (MAC) were MRDneg pre-HCT. At a median 4.5 years follow-up, 1-year transplant-related mortality (TRM) was lower in RIC (13%) than MAC (36%;p=0.001) while the 3-year relapse rate was 49% in RIC and 28% in MAC (p=0.058). Overall survival was similar (RIC 39% [95% CI:27–52] vs. 35% [95% CI:270–44];p=0.62). Patients MRDpos pre-HCT had higher risk of relapse with RIC versus MAC (HR 1.97;p=0.026). However, patients receiving pre-HCT TKI in combination with MRD negativity pre-RIC HCT had superior OS (55%) compared to a similar MRDneg population after MAC (33%; p=0.0042). In multivariate analysis, RIC lowered TRM (HR 0.6; p=0.057), but absence of pre-HCT TKI (HR 1.88;p=0.018), RIC (HR 1.891;p=0.054) and pre-HCT MRDpos (HR 1.6; p=0.070) increased relapse risk. RIC is a valid alternative strategy for Ph+ ALL patients ineligible for MAC and MRDneg status is preferred pre-HCT.
Url:
DOI: 10.1038/leu.2013.253
PubMed: 23989431
PubMed Central: 3951192
Affiliations:
- Allemagne, Arabie saoudite, Australie, Canada, France, Israël, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Caroline du Nord, Floride, Grand Londres, Géorgie (États-Unis), Hambourg, Illinois, Massachusetts, Minnesota, Missouri (État), Ohio, Pennsylvanie, Rhône-Alpes, Tennessee, Texas, Wisconsin, État de New York
- Grenoble, Hambourg, Londres
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Le document en format XML
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Marks</name><affiliation wicri:level="1"><nlm:aff id="A2">Bristol Adult BMT Unit, Bristol Children’s Hospital, Bristol, UNITED KINGDOM</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Bristol Adult BMT Unit, Bristol Children’s Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name><affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Hailin" sort="Wang, Hailin" uniqKey="Wang H" first="Hailin" last="Wang">Hailin Wang</name><affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name><affiliation wicri:level="2"><nlm:aff id="A4">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. 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Artz</name><affiliation wicri:level="2"><nlm:aff id="A7">University of Chicago Medicine, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name><affiliation wicri:level="3"><nlm:aff id="A8">Klinik und Poliklinik fur Stammzelltransplantation, Universitatsklinikum Hamburg-Eppendorf, Hamburg, GERMANY</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Klinik und Poliklinik fur Stammzelltransplantation, Universitatsklinikum Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation wicri:level="3"><nlm:aff id="A9">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation wicri:level="2"><nlm:aff id="A10">Massachusetts General Hospital, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><affiliation wicri:level="2"><nlm:aff id="A11">Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Levine Cancer Institute, Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Drobyski, William R" sort="Drobyski, William R" uniqKey="Drobyski W" first="William R." last="Drobyski">William R. Drobyski</name><affiliation wicri:level="2"><nlm:aff id="A12">Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation wicri:level="3"><nlm:aff id="A13">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Greer, John P" sort="Greer, John P" uniqKey="Greer J" first="John P" last="Greer">John P. Greer</name><affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation wicri:level="1"><nlm:aff id="A15">Princess Margaret Hospital, Toronto, ON, CANADA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Princess Margaret Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation wicri:level="2"><nlm:aff id="A16">All Children’s Hospital, St. Petersburg, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>All Children’s Hospital, St. Petersburg</wicri:cityArea></affiliation></author><author><name sortKey="Kebriaei, Partow" sort="Kebriaei, Partow" uniqKey="Kebriaei P" first="Partow" last="Kebriaei">Partow Kebriaei</name><affiliation wicri:level="2"><nlm:aff id="A17">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation wicri:level="2"><nlm:aff id="A4">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation wicri:level="1"><nlm:aff id="A18">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Victor A" sort="Lewis, Victor A" uniqKey="Lewis V" first="Victor A." last="Lewis">Victor A. Lewis</name><affiliation wicri:level="1"><nlm:aff id="A19">Alberta Children’s Hospital, Calgary, AB, CANADA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Alberta Children’s Hospital, Calgary, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Liesveld, Jane L" sort="Liesveld, Jane L" uniqKey="Liesveld J" first="Jane L." last="Liesveld">Jane L. Liesveld</name><affiliation wicri:level="2"><nlm:aff id="A20">Strong Memorial Hospital, University of Rochester Medical Center; Rochester, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Strong Memorial Hospital, University of Rochester Medical Center; Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation wicri:level="2"><nlm:aff id="A21">Hematology and Internal Medicine, Mayo Clinic Rochester, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Hematology and Internal Medicine, Mayo Clinic Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation wicri:level="2"><nlm:aff id="A22">Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><affiliation wicri:level="2"><nlm:aff id="A23">Baylor University Medical Center, Dallas, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><affiliation wicri:level="2"><nlm:aff id="A24">Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Shands HealthCare and University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Oran, Betul" sort="Oran, Betul" uniqKey="Oran B" first="Betul" last="Oran">Betul Oran</name><affiliation wicri:level="2"><nlm:aff id="A17">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><affiliation wicri:level="2"><nlm:aff id="A25">Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name><affiliation wicri:level="1"><nlm:aff id="A26">Department of Hematology, Rambam Medical Center, Haifa, ISRAEL</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Hematology, Rambam Medical Center, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation wicri:level="2"><nlm:aff id="A27">Barnes Jewish Hospital, Washington University School of Medicine, St. Louis, MO</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Barnes Jewish Hospital, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation wicri:level="2"><nlm:aff id="A28">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H." last="Wiernik">Peter H. Wiernik</name><affiliation wicri:level="2"><nlm:aff id="A29">Our Lady of Mercy Medical Center, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Our Lady of Mercy Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation wicri:level="2"><nlm:aff id="A1">Blood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Blood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23989431</idno><idno type="pmc">3951192</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951192</idno><idno type="RBID">PMC:3951192</idno><idno type="doi">10.1038/leu.2013.253</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002D96</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D96</idno><idno type="wicri:Area/Pmc/Curation">002C46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C46</idno><idno type="wicri:Area/Pmc/Checkpoint">001959</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001959</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003927</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003927</idno><idno type="wicri:Area/PubMed/Curation">003812</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003812</idno><idno type="wicri:Area/PubMed/Checkpoint">003812</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003812</idno><idno type="wicri:Area/Ncbi/Merge">001438</idno><idno type="wicri:Area/Ncbi/Curation">001438</idno><idno type="wicri:Area/Ncbi/Checkpoint">001438</idno><idno type="wicri:doubleKey">0887-6924:2013:Bachanova V:ph:all:patients</idno><idno type="wicri:Area/Main/Merge">004653</idno><idno type="wicri:Area/Main/Curation">004558</idno><idno type="wicri:Area/Main/Exploration">004558</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: Impact of tyrosine kinase inhibitor and minimal residual disease</title><author><name sortKey="Bachanova, Veronika" sort="Bachanova, Veronika" uniqKey="Bachanova V" first="Veronika" last="Bachanova">Veronika Bachanova</name><affiliation wicri:level="2"><nlm:aff id="A1">Blood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Blood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation wicri:level="1"><nlm:aff id="A2">Bristol Adult BMT Unit, Bristol Children’s Hospital, Bristol, UNITED KINGDOM</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Bristol Adult BMT Unit, Bristol Children’s Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name><affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Hailin" sort="Wang, Hailin" uniqKey="Wang H" first="Hailin" last="Wang">Hailin Wang</name><affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name><affiliation wicri:level="2"><nlm:aff id="A4">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation wicri:level="1"><nlm:aff id="A5">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Arellano, Martha" sort="Arellano, Martha" uniqKey="Arellano M" first="Martha" last="Arellano">Martha Arellano</name><affiliation wicri:level="2"><nlm:aff id="A6">Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Winship Cancer Institute, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S." last="Artz">Andrew S. Artz</name><affiliation wicri:level="2"><nlm:aff id="A7">University of Chicago Medicine, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name><affiliation wicri:level="3"><nlm:aff id="A8">Klinik und Poliklinik fur Stammzelltransplantation, Universitatsklinikum Hamburg-Eppendorf, Hamburg, GERMANY</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Klinik und Poliklinik fur Stammzelltransplantation, Universitatsklinikum Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation wicri:level="3"><nlm:aff id="A9">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation wicri:level="2"><nlm:aff id="A10">Massachusetts General Hospital, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><affiliation wicri:level="2"><nlm:aff id="A11">Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Levine Cancer Institute, Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Drobyski, William R" sort="Drobyski, William R" uniqKey="Drobyski W" first="William R." last="Drobyski">William R. Drobyski</name><affiliation wicri:level="2"><nlm:aff id="A12">Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation wicri:level="3"><nlm:aff id="A13">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Greer, John P" sort="Greer, John P" uniqKey="Greer J" first="John P" last="Greer">John P. Greer</name><affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation wicri:level="1"><nlm:aff id="A15">Princess Margaret Hospital, Toronto, ON, CANADA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Princess Margaret Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation wicri:level="2"><nlm:aff id="A16">All Children’s Hospital, St. Petersburg, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>All Children’s Hospital, St. Petersburg</wicri:cityArea></affiliation></author><author><name sortKey="Kebriaei, Partow" sort="Kebriaei, Partow" uniqKey="Kebriaei P" first="Partow" last="Kebriaei">Partow Kebriaei</name><affiliation wicri:level="2"><nlm:aff id="A17">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation wicri:level="2"><nlm:aff id="A4">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation wicri:level="1"><nlm:aff id="A18">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Victor A" sort="Lewis, Victor A" uniqKey="Lewis V" first="Victor A." last="Lewis">Victor A. Lewis</name><affiliation wicri:level="1"><nlm:aff id="A19">Alberta Children’s Hospital, Calgary, AB, CANADA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Alberta Children’s Hospital, Calgary, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Liesveld, Jane L" sort="Liesveld, Jane L" uniqKey="Liesveld J" first="Jane L." last="Liesveld">Jane L. Liesveld</name><affiliation wicri:level="2"><nlm:aff id="A20">Strong Memorial Hospital, University of Rochester Medical Center; Rochester, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Strong Memorial Hospital, University of Rochester Medical Center; Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation wicri:level="2"><nlm:aff id="A21">Hematology and Internal Medicine, Mayo Clinic Rochester, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Hematology and Internal Medicine, Mayo Clinic Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation wicri:level="2"><nlm:aff id="A22">Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><affiliation wicri:level="2"><nlm:aff id="A23">Baylor University Medical Center, Dallas, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><affiliation wicri:level="2"><nlm:aff id="A24">Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Shands HealthCare and University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Oran, Betul" sort="Oran, Betul" uniqKey="Oran B" first="Betul" last="Oran">Betul Oran</name><affiliation wicri:level="2"><nlm:aff id="A17">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><affiliation wicri:level="2"><nlm:aff id="A25">Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name><affiliation wicri:level="1"><nlm:aff id="A26">Department of Hematology, Rambam Medical Center, Haifa, ISRAEL</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Hematology, Rambam Medical Center, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation wicri:level="2"><nlm:aff id="A27">Barnes Jewish Hospital, Washington University School of Medicine, St. Louis, MO</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Barnes Jewish Hospital, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation wicri:level="2"><nlm:aff id="A28">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H." last="Wiernik">Peter H. Wiernik</name><affiliation wicri:level="2"><nlm:aff id="A29">Our Lady of Mercy Medical Center, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Our Lady of Mercy Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation wicri:level="2"><nlm:aff id="A1">Blood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Blood and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="ISSN">0887-6924</idno><idno type="eISSN">1476-5551</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Bone Marrow Transplantation</term><term>Female</term><term>Guinea Pigs</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm, Residual</term><term>Philadelphia Chromosome</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (pathology)</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (surgery)</term><term>Protein-Tyrosine Kinases (antagonists & inhibitors)</term><term>Remission Induction</term><term>Survival Rate</term><term>Transplantation Conditioning</term><term>Transplantation, Homologous</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chromosome Philadelphie</term><term>Cochons d'Inde</term><term>Conditionnement pour greffe</term><term>Femelle</term><term>Humains</term><term>Induction de rémission</term><term>Jeune adulte</term><term>Leucémie-lymphome lymphoblastique à précurseurs B et T ()</term><term>Leucémie-lymphome lymphoblastique à précurseurs B et T (anatomopathologie)</term><term>Maladie résiduelle</term><term>Mâle</term><term>Protein-tyrosine kinases (antagonistes et inhibiteurs)</term><term>Taux de survie</term><term>Transplantation de moelle osseuse</term><term>Transplantation homologue</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Protein-Tyrosine Kinases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Leucémie-lymphome lymphoblastique à précurseurs B et T</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protein-tyrosine kinases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Bone Marrow Transplantation</term><term>Female</term><term>Guinea Pigs</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm, Residual</term><term>Philadelphia Chromosome</term><term>Remission Induction</term><term>Survival Rate</term><term>Transplantation Conditioning</term><term>Transplantation, Homologous</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chromosome Philadelphie</term><term>Cochons d'Inde</term><term>Conditionnement pour greffe</term><term>Femelle</term><term>Humains</term><term>Induction de rémission</term><term>Jeune adulte</term><term>Leucémie-lymphome lymphoblastique à précurseurs B et T</term><term>Maladie résiduelle</term><term>Mâle</term><term>Taux de survie</term><term>Transplantation de moelle osseuse</term><term>Transplantation homologue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The efficacy of reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) for Ph+ acute lymphoblastic leukemia (ALL) is uncertain. We analyzed 197 adults with Ph+ ALL in first complete remission; 67 patients receiving RIC were matched with 130 receiving myeloablative conditioning (MAC) for age, donor type, and HCT year. Over 75% received pre-HCT tyrosine kinase inhibitors (TKI), mostly imatinib; 39% (RIC) and 49% (MAC) were MRD<sup>neg</sup> pre-HCT. At a median 4.5 years follow-up, 1-year transplant-related mortality (TRM) was lower in RIC (13%) than MAC (36%;p=0.001) while the 3-year relapse rate was 49% in RIC and 28% in MAC (p=0.058). Overall survival was similar (RIC 39% [95% CI:27–52] vs. 35% [95% CI:270–44];p=0.62). Patients MRD<sup>pos</sup> pre-HCT had higher risk of relapse with RIC versus MAC (HR 1.97;p=0.026). However, patients receiving pre-HCT TKI in combination with MRD negativity pre-RIC HCT had superior OS (55%) compared to a similar MRD<sup>neg</sup> population after MAC (33%; p=0.0042). In multivariate analysis, RIC lowered TRM (HR 0.6; p=0.057), but absence of pre-HCT TKI (HR 1.88;p=0.018), RIC (HR 1.891;p=0.054) and pre-HCT MRD<sup>pos</sup> (HR 1.6; p=0.070) increased relapse risk. RIC is a valid alternative strategy for Ph+ ALL patients ineligible for MAC and MRD<sup>neg</sup> status is preferred pre-HCT.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moorman, Av" uniqKey="Moorman A">AV Moorman</name></author><author><name sortKey="Harrison, Cj" uniqKey="Harrison C">CJ Harrison</name></author><author><name sortKey="Buck, Ga" uniqKey="Buck G">GA Buck</name></author><author><name sortKey="Richards, Sm" uniqKey="Richards S">SM Richards</name></author><author><name sortKey="Secker Walker, Lm" uniqKey="Secker Walker L">LM Secker-Walker</name></author><author><name sortKey="Martineau, M" uniqKey="Martineau M">M Martineau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizuta, S" uniqKey="Mizuta S">S Mizuta</name></author><author><name sortKey="Matsuo, K" uniqKey="Matsuo K">K Matsuo</name></author><author><name sortKey="Yagasaki, F" uniqKey="Yagasaki F">F 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uniqKey="Pfeifer H">H Pfeifer</name></author><author><name sortKey="Wassmann, B" uniqKey="Wassmann B">B Wassmann</name></author><author><name sortKey="Pavlova, A" uniqKey="Pavlova A">A Pavlova</name></author><author><name sortKey="Wunderle, L" uniqKey="Wunderle L">L Wunderle</name></author><author><name sortKey="Oldenburg, J" uniqKey="Oldenburg J">J Oldenburg</name></author><author><name sortKey="Binckebanck, A" uniqKey="Binckebanck A">A Binckebanck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name></author><author><name sortKey="Minami, Y" uniqKey="Minami Y">Y Minami</name></author><author><name sortKey="Ozawa, Y" uniqKey="Ozawa Y">Y Ozawa</name></author><author><name sortKey="Miyamura, K" uniqKey="Miyamura K">K Miyamura</name></author><author><name sortKey="Naoe, T" uniqKey="Naoe T">T Naoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soiffer, Rj" uniqKey="Soiffer R">RJ Soiffer</name></author><author><name sortKey="Lerademacher, J" uniqKey="Lerademacher J">J Lerademacher</name></author><author><name sortKey="Ho, V" uniqKey="Ho V">V Ho</name></author><author><name sortKey="Kan, F" uniqKey="Kan F">F Kan</name></author><author><name sortKey="Artz, A" uniqKey="Artz A">A Artz</name></author><author><name sortKey="Champlin, Re" uniqKey="Champlin R">RE Champlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riva, G" uniqKey="Riva G">G Riva</name></author><author><name sortKey="Luppi, M" uniqKey="Luppi M">M Luppi</name></author><author><name sortKey="Barozzi, P" uniqKey="Barozzi P">P Barozzi</name></author><author><name sortKey="Quadrelli, C" uniqKey="Quadrelli C">C Quadrelli</name></author><author><name sortKey="Basso, S" uniqKey="Basso S">S Basso</name></author><author><name sortKey="Vallerini, D" uniqKey="Vallerini D">D Vallerini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Topp, Ms" uniqKey="Topp M">MS Topp</name></author><author><name sortKey="Kufer, P" uniqKey="Kufer P">P Kufer</name></author><author><name sortKey="Gokbuget, N" uniqKey="Gokbuget N">N Gokbuget</name></author><author><name sortKey="Goebeler, M" uniqKey="Goebeler M">M Goebeler</name></author><author><name sortKey="Klinger, M" uniqKey="Klinger M">M Klinger</name></author><author><name sortKey="Neumann, S" uniqKey="Neumann S">S Neumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foa, R" uniqKey="Foa R">R Foa</name></author><author><name sortKey="Vitale, A" uniqKey="Vitale A">A Vitale</name></author><author><name sortKey="Vignetti, M" uniqKey="Vignetti M">M Vignetti</name></author><author><name sortKey="Meloni, G" uniqKey="Meloni G">G Meloni</name></author><author><name sortKey="Guarini, A" uniqKey="Guarini A">A Guarini</name></author><author><name sortKey="De Propris, Ms" uniqKey="De Propris M">MS De Propris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottmann, Og" uniqKey="Ottmann O">OG Ottmann</name></author><author><name sortKey="Larson, Ra" uniqKey="Larson R">RA Larson</name></author><author><name sortKey="Kantarjian, Hm" uniqKey="Kantarjian H">HM Kantarjian</name></author><author><name sortKey="Le Coutre, Pd" uniqKey="Le Coutre P">PD le Coutre</name></author><author><name sortKey="Baccarani, M" uniqKey="Baccarani M">M Baccarani</name></author><author><name sortKey="Hochhaus, A" uniqKey="Hochhaus A">A Hochhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grupp, Sa" uniqKey="Grupp S">SA Grupp</name></author><author><name sortKey="Kalos, M" uniqKey="Kalos M">M Kalos</name></author><author><name sortKey="Barrett, D" uniqKey="Barrett D">D Barrett</name></author><author><name sortKey="Aplenc, R" uniqKey="Aplenc R">R Aplenc</name></author><author><name sortKey="Porter, Dl" uniqKey="Porter D">DL Porter</name></author><author><name sortKey="Rheingold, Sr" uniqKey="Rheingold S">SR Rheingold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bassan, R" uniqKey="Bassan R">R Bassan</name></author><author><name sortKey="Spinelli, O" uniqKey="Spinelli O">O Spinelli</name></author><author><name sortKey="Oldani, E" uniqKey="Oldani E">E Oldani</name></author><author><name sortKey="Intermesoli, T" uniqKey="Intermesoli T">T Intermesoli</name></author><author><name sortKey="Tosi, M" uniqKey="Tosi M">M Tosi</name></author><author><name sortKey="Peruta, B" uniqKey="Peruta B">B Peruta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfeifer, H" uniqKey="Pfeifer H">H Pfeifer</name></author><author><name sortKey="Wassmann, B" uniqKey="Wassmann B">B Wassmann</name></author><author><name sortKey="Bethge, W" uniqKey="Bethge W">W Bethge</name></author><author><name sortKey="Dengler, J" uniqKey="Dengler J">J Dengler</name></author><author><name sortKey="Bornhauser, M" uniqKey="Bornhauser M">M Bornhauser</name></author><author><name sortKey="Stadler, M" uniqKey="Stadler M">M Stadler</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Arabie saoudite</li><li>Australie</li><li>Canada</li><li>France</li><li>Israël</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Caroline du Nord</li><li>Floride</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Hambourg</li><li>Illinois</li><li>Massachusetts</li><li>Minnesota</li><li>Missouri (État)</li><li>Ohio</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Tennessee</li><li>Texas</li><li>Wisconsin</li><li>État de New York</li></region><settlement><li>Grenoble</li><li>Hambourg</li><li>Londres</li></settlement></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Bachanova, Veronika" sort="Bachanova, Veronika" uniqKey="Bachanova V" first="Veronika" last="Bachanova">Veronika Bachanova</name></region><name sortKey="Arellano, Martha" sort="Arellano, Martha" uniqKey="Arellano M" first="Martha" last="Arellano">Martha Arellano</name><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S." last="Artz">Andrew S. Artz</name><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name><name sortKey="Drobyski, William R" sort="Drobyski, William R" uniqKey="Drobyski W" first="William R." last="Drobyski">William R. Drobyski</name><name sortKey="Greer, John P" sort="Greer, John P" uniqKey="Greer J" first="John P" last="Greer">John P. Greer</name><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><name sortKey="Kebriaei, Partow" sort="Kebriaei, Partow" uniqKey="Kebriaei P" first="Partow" last="Kebriaei">Partow Kebriaei</name><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><name sortKey="Liesveld, Jane L" sort="Liesveld, Jane L" uniqKey="Liesveld J" first="Jane L." last="Liesveld">Jane L. Liesveld</name><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><name sortKey="Oran, Betul" sort="Oran, Betul" uniqKey="Oran B" first="Betul" last="Oran">Betul Oran</name><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><name sortKey="Wang, Hailin" sort="Wang, Hailin" uniqKey="Wang H" first="Hailin" last="Wang">Hailin Wang</name><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H." last="Wiernik">Peter H. Wiernik</name><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name></noRegion><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name></noRegion></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name></region></country><country name="Canada"><noRegion><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name></noRegion><name sortKey="Lewis, Victor A" sort="Lewis, Victor A" uniqKey="Lewis V" first="Victor A." last="Lewis">Victor A. Lewis</name></country><country name="Australie"><noRegion><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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